A.I.M.E. Higher Scientific Communications was started with the goal of helping advance scientific discovery by breaking down barriers that currently exist in the way science is discussed and disseminated
Leadership
Co-founders of A.I.M.E. Higher Scientific Communications
Mackenzie Hagan, Ph.D.
Dr. Mackenzie Hagan earned her Ph.D. in Cellular Biology and Anatomy from Augusta University in Augusta, Georgia, USA in May 2021.
She received her Bachelor of Science in Kinesiology with an emphasis in Athletic Training from University of Wisconsin Oshkosh. Prior to enrolling in college, Mackenzie was Nationally Certified as an Emergency Medical Technician. She has an extensive background in orthopedics, with 10 years of combined academic experience in bone biology, sports medicine, and emergency medicine with additional expertise in cancer biology. She has seven publications in peer-reviewed journals from publishers such as Elsevier, Wiley, Springer, and Spandidos.
Hagan ML, Mander S, Joseph C, McGrath M, Barrett A, et al., Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER+ breast cancer cells. Int J Oncol. 2023 Feb;62(2):20. doi: 10.3892/ijo.2022.5468. Epub 2022 Dec 16. PMID: 36524361; PMCID: PMC9854236.
Hagan ML, Balayan V, McGee-Lawrence ME. Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues. Bone. 2021 Aug;149:115970. doi: 10.1016/j.bone.2021.115970. Epub 2021 Apr 21. PMID: 33892174; PMCID: PMC8217198.
Hagan ML, Yu K, Zhu J, Vinson BN, Roberts RL, et al. Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton. Aging Cell. 2020 Jan;19(1):e13056. doi: 10.1111/acel.13056. Epub 2019 Nov 19. PMID: 31743583; PMCID: PMC6974724.
Hagan ML, Bahraini A, Pierce JL, Bass SM, Yu K, et al. Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival. Calcif Tissue Int. 2019 Feb;104(2):224-234. doi: 10.1007/s00223-018-0487-0. Epub 2018 Oct 24. PMID: 30357446; PMCID: PMC6452877.
Yu K, Sellman DP, Bahraini A, Hagan ML, Elsherbini A, et al. Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone. J Orthop Res. 2018 Feb;36(2):653-662. doi: 10.1002/jor.23665. Epub 2017 Aug 11. PMID: 28755471; PMCID: PMC5788741.
Hagan M, Ashraf M, Kim IM, Weintraub NL, Tang Y. Effective regeneration of dystrophic muscle using autologous iPSC-derived progenitors with CRISPR-Cas9 mediated precise correction. Med Hypotheses. 2018 Jan;110:97-100. doi: 10.1016/j.mehy.2017.11.009. Epub 2017 Nov 23. PMID: 29317080; PMCID: PMC5793935.
Hagan M, Zhou M, Ashraf M, Kim IM, Su H, et al.
Long noncoding RNAs and their roles in skeletal muscle fate determination. Noncoding RNA Investig. 2017 Dec;1:24. doi: 10.21037/ncri.2017.12.01. Epub 2017 Dec 13. PMID: 29451560; PMCID: PMC5810974.
Marissa Seamon, Ph.D.
Dr. Marissa Seamon earned her Ph.D. in Neuroscience from Augusta University in Augusta, Georgia, USA in December 2021.
She received her Bachelor of Arts in Psychology with a collateral major in Neuroscience from Coe College in Cedar Rapids, Iowa, USA. Her graduate school research included animal studies in obesity research and clinical Parkinson's disease research. Before graduate school, Marissa worked as a Residential Counselor in a level IV Psychiatric Residential Treatment Facility. She has seven publications in peer-reviewed journals from publishers such as MDPI, Elsevier, Frontiers, Springer, and American Journal of Physiology.
Giri B, Seamon M, Banerjee A, Chauhan S, Purohit S, et al. Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease. Metab Brain Dis. 2022 Aug;37(6):1687-1696. doi: 10.1007/s11011-021-00735-2. Epub 2021 Apr 21. PMID: 33881722.
Wakade C, Chong R, Seamon M, Purohit S, Giri B, et al. Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson's Disease: A Single-Center, Randomized, Placebo-Controlled Trial. Biomedicines. 2021 Dec 10;9(12):1881. doi: 10.3390/biomedicines9121881. PMID: 34944695; PMCID: PMC8698595.
Chong R, Wakade C, Seamon M, Giri B, Morgan J, et al. Niacin Enhancement for Parkinson's Disease: An Effectiveness Trial. Front Aging Neurosci. 2021 Jun 17;13:667032. doi: 10.3389/fnagi.2021.667032. PMID: 34220485; PMCID: PMC8245760.
Karunaratne TB, Okereke C, Seamon M, Purohit S, Wakade C, et al. Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease. Nutrients. 2020 Dec 23;13(1):28. doi: 10.3390/nu13010028. PMID: 33374784; PMCID: PMC7824468.
Seamon M, Purohit S, Giri B, Baban B, Morgan J, et al. Niacin for Parkinson's disease. Clin Exp Neuroimmunol. 2020 Feb 13; 11: 47-56. doi: 10.1111/cen3.12553.
Seamon M, Ahn W, Li AJ, Ritter S, Harris RBS. Leptin receptor-expressing neurons in ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E586-E596. doi: 10.1152/ajpendo.00205.2019. Epub 2019 Jul 30. PMID: 31361549; PMCID: PMC6842917.
Giri B, Belanger K, Seamon M, Bradley E, Purohit S, et al. Niacin Ameliorates Neuro-Inflammation in Parkinson's Disease via GPR109A. Int J Mol Sci. 2019 Sep 14;20(18):4559. doi: 10.3390/ijms20184559. PMID: 31540057; PMCID: PMC6770365.
A.I.M.E. Higher Scientific Communications is a limited liability company established in March 2022. Prior to partnering, Marissa and Mackenzie had over a year of freelancing experience specializing in editorial, writing, and content creation for clients working in Academia, Industry, and Continuing Medical Education.
